FABP4 as a biomarker for knee osteoarthritis

Chaofan Zhang, Teng Li, Kwong Yuen Chiu, Chunyi Wen, Aimin Xu, Chun Hoi Yan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalBiomarkers in Medicine
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • FABP4
  • infrapatellar fat pad
  • osteoarthritis

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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