FABP4 as a biomarker for knee osteoarthritis

Chaofan Zhang; Teng Li; Kwong Yuen Chiu; Chunyi Wen; Aimin Xu; Chun Hoi Yan

doi:10.2217/bmm-2017-0207

FABP4 as a biomarker for knee osteoarthritis

Chaofan Zhang, Teng Li, Kwong Yuen Chiu, Chunyi Wen, Aimin Xu, Chun Hoi Yan

Research output: Journal article publication › Journal article › Academic research › peer-review

28 Citations (Scopus)

Abstract

Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.

Original language	English
Pages (from-to)	107-118
Number of pages	12
Journal	Biomarkers in Medicine
Volume	12
Issue number	2
DOIs	https://doi.org/10.2217/bmm-2017-0207
Publication status	Published - 1 Feb 2018

Keywords

FABP4
infrapatellar fat pad
osteoarthritis

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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10.2217/bmm-2017-0207

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title = "FABP4 as a biomarker for knee osteoarthritis",

abstract = "Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.",

keywords = "FABP4, infrapatellar fat pad, osteoarthritis",

author = "Chaofan Zhang and Teng Li and Chiu, {Kwong Yuen} and Chunyi Wen and Aimin Xu and Yan, {Chun Hoi}",

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AU - Zhang, Chaofan

AU - Li, Teng

AU - Chiu, Kwong Yuen

AU - Wen, Chunyi

AU - Xu, Aimin

AU - Yan, Chun Hoi

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.

AB - Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.

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FABP4 as a biomarker for knee osteoarthritis

Abstract

Keywords

ASJC Scopus subject areas

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