Extent and distribution of linkage disequilibrium around the SLC11A1 locus

Shea Ping Yip, K. H. Leung, C. K. Lin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

22 Citations (Scopus)

Abstract

The SLC11A1 (or NRAMP1) locus on human chromosome 2q35 encodes for the protein solute carrier family 11, member 1. It is expressed in macrophages and involved in the early stages of macrophage priming and activation. Different association studies have shown that the SLC11A1 gene affects susceptibility to infectious diseases and autoimmune inflammatory diseases. Although functional SLC11A1 polymorphisms may account for its role in affecting the susceptibility to these diseases, the positive association can also be because of flanking polymorphisms showing linkage disequilibrium (LD) with this locus. This is the first systematic study to investigate the LD pattern within and around the gene. LD was investigated by genotyping 17 genetic markers in a Chinese population (n = 360). The results indicate that LD is maintained at least 110 kb both upstream and downstream of the locus. The complex LD pattern demands that association studies with SLC11A1 should be carried out with both 5′ and 3′ markers. The strong LD between IL8RB and the 5′ SLC11A1 markers also dictates that IL8RB be tested for association with these diseases. Thus, positive association with SLC11A1 should be interpreted cautiously, and IL8RB should also be considered as a potential candidate susceptibility gene unless proven otherwise.
Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalGenes and Immunity
Volume4
Issue number3
DOIs
Publication statusPublished - 1 Apr 2003

Keywords

  • Candidate susceptibility genes
  • IL8RA
  • IL8RB
  • Linkage disequilibrium
  • NRAMP1
  • SLC11A1

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

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