Expression of Hex mRNA in early murine postimplantation embryo development

Wee-Keong Vincent Keng, Kazuhiro E. Fujimori, Zaw Myint, Nobuaki Tamamaki, Yoshiaki Nojyo, Tamio Noguchi

Research output: Journal article publicationJournal articleAcademic researchpeer-review

48 Citations (Scopus)


The onset of Hex expression and its role in early murine development was analyzed using in situ hybridization. Hex mRNA was first detected in the chorion of the ectoplacental cavity and weakly at the visceral endoderm of the future yolk sac at embryonic age (E) 7.5. Expression in embryonic tissues was detected exclusively in the hepatic anlage and thyroid primordium at E 9.5. At E 12.5 and E 15.5, Hex expression persisted in the fetal liver and thyroid, and was also detected in the fetal lung. These results suggest that Hex has its role in differentiation and/or organogenesis of several embryonic tissues.
Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalFEBS Letters
Issue number2
Publication statusPublished - 17 Apr 1998
Externally publishedYes


  • Hex
  • In situ hybridization
  • Liver
  • Lung
  • Murine embryo
  • Thyroid

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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