Exploration of Aryl Phosphates in Palladium-Catalyzed Mono-α-arylation of Aryl and Heteroaryl Ketones

Xiangmeng Chen, Zicong Chen, Chau Ming So

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)


This paper presents the first general examples of selective palladium-catalyzed mono-α-arylation of aryl and heteroaryl ketones with aryl phosphates. The catalyst system, consisting of [Pd(2-butenyl)Cl] 2 and MorDalPhos, exhibited high catalytic reactivity toward this reaction. A wide range of aryl phosphates were efficiently coupled with aryl and heteroaryl ketones with good selectivity. Excellent-to-good product yields were afforded. The gram-scale reaction was conducted smoothly. Reductive elimination or transmetalation might be a rate-determining step in this reaction.

Original languageEnglish
Pages (from-to)6337-6346
Number of pages10
JournalJournal of Organic Chemistry
Issue number10
Publication statusPublished - 17 May 2019

ASJC Scopus subject areas

  • Organic Chemistry

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