TY - JOUR
T1 - Experimentally induced myopia and myopic astigmatism alter retinal electrophysiology in chickens
AU - Vyas, Sonal Aswin
AU - Lakshmanan, Yamunadevi
AU - Chan, Ho Lung Henry
AU - Leung, Tsz Wing
AU - Kee, Chea Su
N1 - Funding Information:
This study was funded by RGC General Research Fund (PolyU 151001/17M, 151004/18M), Innovation and Technology Commission InnoHK CEVR project 1.5 and External Research Fund: Collaborative Research (ZG7B) from The Hong Kong Polytechnic University. The authors thank the University Research Facility for Behavioral and Systems Neuroscience (UBSN) for technical and facility support.
Funding Information:
This study was funded by RGC General Research Fund (PolyU 151001/17M, 151004/18M), Innovation and Technology Commission InnoHK CEVR project 1.5 and External Research Fund: Collaborative Research (ZG7B) from The Hong Kong Polytechnic University. The authors thank the University Research Facility for Behavioral and Systems Neuroscience (UBSN) for technical and facility support.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12/7
Y1 - 2022/12/7
N2 - Myopia (or “short-sightedness”) and astigmatism are major causes of visual impairment worldwide. Significant amounts of astigmatism are frequently observed in infants and have been associated with myopia development. Although it is well established that both myopia and astigmatism are associated with ocular structural changes from anterior to posterior segments, very little is known on how these refractive errors alter retinal functions. This study investigated the effects of experimentally induced myopia and myopic-astigmatism on retinal electrophysiology by using an image-guided, multifocal global flash stimulation in chickens, a widely used animal model for refractive error development. Myopia and myopic-astigmatism were experimentally induced, respectively, by wearing spherical (− 10 D, n = 12) and sphero-cylindrical lenses (− 6.00 DS/− 8.00 DCx90: Hyperopic With-The Rule, H-WTR, n = 15; − 6.00 DS/− 8.00 DCx180: Hyperopic Against-The-Rule, H-ATR, n = 11) monocularly for a week (post-hatching day 5 to 12). An aged-matched control group without any lens treatment provided normal data (n = 12). Multifocal electrophysiological results revealed significant regional variation in the amplitude of induced component (IC) (central greater than peripheral; both p
AB - Myopia (or “short-sightedness”) and astigmatism are major causes of visual impairment worldwide. Significant amounts of astigmatism are frequently observed in infants and have been associated with myopia development. Although it is well established that both myopia and astigmatism are associated with ocular structural changes from anterior to posterior segments, very little is known on how these refractive errors alter retinal functions. This study investigated the effects of experimentally induced myopia and myopic-astigmatism on retinal electrophysiology by using an image-guided, multifocal global flash stimulation in chickens, a widely used animal model for refractive error development. Myopia and myopic-astigmatism were experimentally induced, respectively, by wearing spherical (− 10 D, n = 12) and sphero-cylindrical lenses (− 6.00 DS/− 8.00 DCx90: Hyperopic With-The Rule, H-WTR, n = 15; − 6.00 DS/− 8.00 DCx180: Hyperopic Against-The-Rule, H-ATR, n = 11) monocularly for a week (post-hatching day 5 to 12). An aged-matched control group without any lens treatment provided normal data (n = 12). Multifocal electrophysiological results revealed significant regional variation in the amplitude of induced component (IC) (central greater than peripheral; both p
UR - http://www.scopus.com/inward/record.url?scp=85143529257&partnerID=8YFLogxK
U2 - 10.1038/s41598-022-25075-8
DO - 10.1038/s41598-022-25075-8
M3 - Journal article
SN - 2045-2322
VL - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 21180
ER -