TY - JOUR
T1 - Excess cardiovascular mortality across multiple COVID-19 waves in the United States from March 2020 to March 2022
AU - Han, Lefei
AU - Zhao, Shi
AU - Li, Siyuan
AU - Gu, Siyu
AU - Deng, Xiaobei
AU - Yang, Lin
AU - Ran, Jinjun
N1 - Funding Information:
This work was supported by the Shanghai Science and Technology Development Foundation, 22YF1421100 (J.R.) and Health Medical Research Fund—Commissioned Research on COVID-19, COVID1903007 (L.Y.). The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review or approval of the paper; and decision to submit the paper for publication. We thank S. Sun (Capital Medical University) and W. Cao (Peking University) for their helpful comments.
Funding Information:
This work was supported by the Shanghai Science and Technology Development Foundation, 22YF1421100 (J.R.) and Health Medical Research Fund—Commissioned Research on COVID-19, COVID1903007 (L.Y.). The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review or approval of the paper; and decision to submit the paper for publication. We thank S. Sun (Capital Medical University) and W. Cao (Peking University) for their helpful comments.
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2023/3
Y1 - 2023/3
N2 - The COVID-19 pandemic has limited the access of patients with cardiovascular diseases to healthcare services, causing excess deaths. However, a detailed analysis of temporal variations of excess cardiovascular mortality during the COVID-19 pandemic has been lacking. Here we estimate time-varied excess cardiovascular deaths (observed deaths versus expected deaths predicted by the negative binomial log-linear regression model) in the United States. From March 2020 to March 2022 there were 90,160 excess cardiovascular deaths, or 4.9% more cardiovascular deaths than expected. Two large peaks of national excess cardiovascular mortality were observed during the periods of March–June 2020 and June–November 2021, coinciding with two peaks of COVID-19 deaths, but the temporal patterns varied by state, age, sex and race and ethnicity. The excess cardiovascular death percentages were 5.7% and 4.0% in men and women, respectively, and 3.6%, 8.8%, 7.5% and 7.7% in non-Hispanic White, Black, Asian and Hispanic people, respectively. Our data highlight an urgent need for healthcare services optimization for patients with cardiovascular diseases in the COVID-19 era.
AB - The COVID-19 pandemic has limited the access of patients with cardiovascular diseases to healthcare services, causing excess deaths. However, a detailed analysis of temporal variations of excess cardiovascular mortality during the COVID-19 pandemic has been lacking. Here we estimate time-varied excess cardiovascular deaths (observed deaths versus expected deaths predicted by the negative binomial log-linear regression model) in the United States. From March 2020 to March 2022 there were 90,160 excess cardiovascular deaths, or 4.9% more cardiovascular deaths than expected. Two large peaks of national excess cardiovascular mortality were observed during the periods of March–June 2020 and June–November 2021, coinciding with two peaks of COVID-19 deaths, but the temporal patterns varied by state, age, sex and race and ethnicity. The excess cardiovascular death percentages were 5.7% and 4.0% in men and women, respectively, and 3.6%, 8.8%, 7.5% and 7.7% in non-Hispanic White, Black, Asian and Hispanic people, respectively. Our data highlight an urgent need for healthcare services optimization for patients with cardiovascular diseases in the COVID-19 era.
UR - http://www.scopus.com/inward/record.url?scp=85165149095&partnerID=8YFLogxK
U2 - 10.1038/s44161-023-00220-2
DO - 10.1038/s44161-023-00220-2
M3 - Journal article
AN - SCOPUS:85165149095
SN - 2731-0590
VL - 2
SP - 322
EP - 333
JO - Nature Cardiovascular Research
JF - Nature Cardiovascular Research
IS - 3
ER -