TY - GEN
T1 - Evaluation of Central Fatigue in Post-stroke Rehabilitation: A Pilot Study
AU - Xu, Yuchen
AU - Poon, Wai Sang
AU - Zheng, Yongping
AU - Zhang, Shaomin
AU - Hu, Xiaoling
N1 - Funding Information:
This project was financially supported by the Chinese National Key R&D Program (2017YFE0195500), the Key R&D Program of Zhejiang Province (2021C03050, 2021C03003) and the National Natural Science Foundation of China (81771959, 31627802, 31371001).
Publisher Copyright:
© 2021 IEEE.
PY - 2021/11
Y1 - 2021/11
N2 - Central fatigue induced by excessive rehabilitation training would limit motor activity or even damage the post-stroke motor function recovery. However, the central fatigue progress during training is unclear and ignored in post-stroke rehabilitation. In this study, we tried to investigate the changes in central fatigue with fractal dimension (FD) of electromyography (EMG) at different peripheral fatigue levels based on the intracerebral haemorrhage (ICH) model. Ten Sprague-Dawley rats with ICH and EMG electrodes implantation were randomly distributed into two groups: the forced training (FOR) group with exhausted peripheral fatigue level (n=5) and fatigue-controlled (FAT) group (n=5) with peripheral fatigue constrained in moderate level. A higher central fatigue level was found in the FOR group (P<0.0001), and the central fatigue could be alleviated by peripheral fatigue-based modulation in the FAT group. The FAT group with less central fatigue achieved significantly better motor function recovery (P<0.0001), and it might be related to the recovery in the ability of motor unit recruitments.
AB - Central fatigue induced by excessive rehabilitation training would limit motor activity or even damage the post-stroke motor function recovery. However, the central fatigue progress during training is unclear and ignored in post-stroke rehabilitation. In this study, we tried to investigate the changes in central fatigue with fractal dimension (FD) of electromyography (EMG) at different peripheral fatigue levels based on the intracerebral haemorrhage (ICH) model. Ten Sprague-Dawley rats with ICH and EMG electrodes implantation were randomly distributed into two groups: the forced training (FOR) group with exhausted peripheral fatigue level (n=5) and fatigue-controlled (FAT) group (n=5) with peripheral fatigue constrained in moderate level. A higher central fatigue level was found in the FOR group (P<0.0001), and the central fatigue could be alleviated by peripheral fatigue-based modulation in the FAT group. The FAT group with less central fatigue achieved significantly better motor function recovery (P<0.0001), and it might be related to the recovery in the ability of motor unit recruitments.
UR - http://www.scopus.com/inward/record.url?scp=85122541402&partnerID=8YFLogxK
U2 - 10.1109/EMBC46164.2021.9630323
DO - 10.1109/EMBC46164.2021.9630323
M3 - Conference article published in proceeding or book
C2 - 34892642
AN - SCOPUS:85122541402
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 6687
EP - 6690
BT - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Y2 - 1 November 2021 through 5 November 2021
ER -