Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice

S. Y. Pan, Yifan Han, Z. L. Yu, R. Yang, H. Dong, K. M. Ko

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8 Citations (Scopus)


The potential of tacrine in altering cognitive/behavioral function as well as in causing toxicity was evaluated in mice of 17 and 30 days of age. Cognitive and behavioral studies were performed using a step-through passive avoidance task and a habituation open-field test with a 24-h retention interval. Tacrine was subcutaneously injected (1.25-80 μmol/kg) 30 min prior to the first session of both tests. During the training session in step-through task, tacrine treatment dose-dependently decreased the number of footshocks, with IC50values being 7.8 and 23.3 μmol/kg in 17- and 30-day-old mice, respectively. Treatment with tacrine at a low dose (5 μmol/kg) significantly prolonged the retention latency in 17-day-old mice only, but it shortened the retention latency at high doses of 20 and 40 μmol/kg in 17- and 30-day-old, respectively. During the acquisition session in the open-field test, tacrine treatment dose-dependently decreased the locomotor activity in 17- and 30-day-old mice, with IC50values being 15.1 and 24.7 μmol/kg, respectively. High doses of tacrine invariably increased the locomotor activity during the recall session. Tacrine treatment at a dose of 40 μmol/kg caused a significant increase in serum alanine aminotransferase activity in 17- and 30-day-old mice at 6 h post-dosing, with the extent of stimulation in 30-day-old mice being more prominent. In conclusion, tacrine was more potent in enhancing/disrupting the cognitive function, inhibiting locomotor activity as well as in causing hepatotoxicity in 17-day-old than in 30-day-old mice.
Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalPharmacology Biochemistry and Behavior
Issue number1
Publication statusPublished - 1 Sep 2006
Externally publishedYes


  • Acute toxicity
  • Defecation
  • Developmental changes
  • Hepatotoxicity
  • Locomotor
  • Open-field memory
  • Passive-avoidance response
  • Tacrine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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