@article{e455497531ea492fa5c1fb44a7afaa4e,
title = "Euryale Ferox Seed-Inspired Superlubricated Nanoparticles for Treatment of Osteoarthritis",
abstract = "Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3-sulfopropyl methacrylate potassium salt)-grafted mesoporous silica nanoparticles (MSNs-NH2@PSPMK), is biomimicked and synthesized via a one-step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti-inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS-loaded MSNs-NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis.",
keywords = "bioinspired, lubrication, nanoparticles, osteoarthritis, photopolymerization",
author = "Yufei Yan and Tao Sun and Hongbo Zhang and Xiuling Ji and Yulong Sun and Xin Zhao and Lianfu Deng and Jin Qi and Wenguo Cui and Santos, {H{\'e}lder A.} and Hongyu Zhang",
note = "Funding Information: Y.Y., T.S., and H.Z. contributed equally to this work. This study was financially supported by National Key Research and Development Program of China (2018YFC1106200 and 2018YFC1106204), National Natural Science Foundation of China (51675296, 51873107, and 81572099), Ng Teng Fong Charitable Foundation (202-276-132-13), Research Fund of State Key Laboratory of Tribology, Tsinghua University, China (SKLT2018B08), Shanghai Science and Technology Commission (18ZR1434200 and 17140900102), Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20171906), Shanghai Jiao Tong University “Medical and Research” Program (ZH2018ZDA04), and Major Program for the Fundamental Research of Shanghai (2014ZYJB0302). H.Z. acknowledges financial support from Jane and Aatos Erkko Foundation (grant no. 4704010), Academy of Finland (grant no. 297580), and Sigrid Jus{\'e}lius Foundation (decision no. 28001830K1). Prof. H. A. Santos acknowledges financial support from the HiLIFE Research Funds and the Sigrid Jus{\'e}lius Foundation (decision no. 4704580). Funding Information: Y.Y., T.S., and H.Z. contributed equally to this work. This study was financially supported by National Key Research and Development Program of China (2018YFC1106200 and 2018YFC1106204), National Natural Science Foundation of China (51675296, 51873107, and 81572099), Ng Teng Fong Charitable Foundation (202-276-132-13), Research Fund of State Key Laboratory of Tribology, Tsinghua University, China (SKLT2018B08), Shanghai Science and Technology Commission (18ZR1434200 and 17140900102), Shanghai Municipal Education Commission?Gaofeng Clinical Medicine Grant Support (20171906), Shanghai Jiao Tong University ?Medical and Research? Program (ZH2018ZDA04), and Major Program for the Fundamental Research of Shanghai (2014ZYJB0302). H.Z. acknowledges financial support from Jane and Aatos Erkko Foundation (grant no. 4704010), Academy of Finland (grant no. 297580), and Sigrid Jus?lius Foundation (decision no. 28001830K1). Prof. H. A. Santos acknowledges financial support from the HiLIFE Research Funds and the Sigrid Jus?lius Foundation (decision no. 4704580). Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jan,
day = "24",
doi = "10.1002/adfm.201807559",
language = "English",
volume = "29",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH Verlag",
number = "4",
}