Estimation of minimally important difference of the EQ-5D-5L utility scores among patients with either hypertension or diabetes or both: A cross-sectional study in Hong Kong

Richard Huan Xu (Corresponding Author), Eliza Lai Yi Wong (Corresponding Author), Annie Wai Ling Cheung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Objective To estimate and report the minimally important difference (MID) of the EuroQol five-dimensional five-level questionnaire (EQ-5D-5L) using the Hong Kong (HK) utility score among patients with either hypertension or diabetes or both. Design Data were analysed using secondary data analysis based on a cross-sectional study assessing patients' experiences in HK. Setting A representative sample was recruited from 26 specialist outpatient clinics in HK. Participants We analysed data from 2231 and 662 patients who reported having hypertension or diabetes alone, respectively, and 874 patients had these two diseases. Intervention An instrument-defined approach was applied to estimate MID stratified according to sex and age for the three subpopulations. Results The overall MID (oMID) estimates were 0.089, 0.086 and 0.089 for patients with hypertension or diabetes alone and with these two diseases, respectively. The adjusted MID (aMID) estimate was smaller than the oMID, and the improved MID was larger than the deteriorated MID. Women had larger oMID but smaller aMID than men. Younger respondents had larger aMID than older respondents. Effect sizes ranged from 0.30 to 0.503, which fit our preset criteria. Conclusion Four types of MID of the EQ-5D utility score for patients with hypertension or diabetes alone and with these two diseases were reported. Variations in the MID estimates should be further explored in other populations or using different statistical methods.

Original languageEnglish
Article numbere039397
JournalBMJ Open
Volume10
Issue number11
DOIs
Publication statusPublished - 26 Nov 2020
Externally publishedYes

Keywords

  • diabetes & endocrinology
  • general diabetes
  • health economics
  • hypertension

ASJC Scopus subject areas

  • Medicine(all)

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