Abstract
An electrochemical method for the investigation and comparison of anti-Alzheimer medications that is based on the inhibition of the acetylcholinesterase is presented. The developed amperometric biosensor determines the in-vitro inhibition of the acetylcholinesterase that is co-immobilized with choline oxidase on the working electrode surface of a three-electrode system using gel entrapment. The sensor has been applied to determine the IC50values of two known and one newly developed Alzheimer remedy. A simultaneous measurement with the photometric standard method shows the applicability of our method for fast drug screening. (C) 2000 Elsevier Science S.A.
Original language | English |
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Pages (from-to) | 541-547 |
Number of pages | 7 |
Journal | Biosensors and Bioelectronics |
Volume | 15 |
Issue number | 9-10 |
DOIs | |
Publication status | Published - 1 Nov 2000 |
Externally published | Yes |
Keywords
- Acetylcholinesterase inhibitors
- Alzheimer's disease
- Biosensor
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Biomedical Engineering
- Electrochemistry