Entropy Learning for Dynamic Treatment Regimes

Binyan Jiang, Rui Song, Jialiang Li, Donglin Zeng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Estimating optimal individualized treatment rules (ITRs) in single- or multi-stage clinical trials is a key element of personalized medicine and, as a result, is receiving increasing attention within the statistical community. Recent works have suggested that machine learning approaches can provide significantly better estimations than those of model-based methods. However, a proper inference for es- timated ITRs has not been well established for machine learning-based approaches. In this paper, we propose an entropy learning approach for estimating optimal ITRs. We obtain the asymptotic distributions for the estimated rules in order to provide a valid inference. The proposed approach is demonstrated to perform well through extensive simulation studies. Finally, we analyze data from a multi-stage clinical trial for depression patients. Our results offer novel findings not revealed by existing approaches.
Original languageEnglish
Pages (from-to)1633-1656
Number of pages24
JournalStatistica Sinica
Volume29
Issue number4
DOIs
Publication statusPublished - Oct 2019

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