TY - JOUR
T1 - Enhancing NIR-II Phosphorescence through Phosphorescence Resonance Energy Transfer for Tumor-Hypoxia Imaging
AU - Zhang, Wansu
AU - Chen, Shangyu
AU - Ye, Shuai
AU - Sun, Pengfei
AU - Fan, Quli
AU - Song, Jun
AU - Zeng, Pengju
AU - Qu, Jun Le
AU - Wong, Wai Yeung
N1 - Funding Information:
This work was financially supported by National Natural Science Foundation of China (Nos. 61620106016, 61835009, 61775145, 62175161, 52073242, 51873176, 61975132), Shenzhen Basic Research Program (No. JCYJ20210324095810028), Hong Kong Research Grants Council (No. PolyU153058/19P), the CAS-Croucher Funding Scheme for Joint Laboratories (No. ZH4A), the Guangdong-Hong Kong-Macao Joint Laboratory for Optoelectronic and Magnetic Functional Materials (No. 2019B121205002), Hong Kong Polytechnic University, Research Institute for Smart Energy (CDAQ) and Miss Clarea Au for the Endowed Professorship in Energy (No. 847S).
Publisher Copyright:
© 2023 American Chemical Society. All rights reserved.
PY - 2023/1/2
Y1 - 2023/1/2
N2 - Phosphorescence probes have emerged as a promising hypoxia detector for their excellent characters of long luminescence lifetime, large Stokes shift, and oxygen sensitivity. However, the low quantum yields of organic phosphorescence probes in the second near-infrared wavelength window (NIR-II, 1000-1700 nm) hinder their further development of NIR-II hypoxia imaging. Herein, this study reports a new NIR-II phosphorescence probe (PRET NPs) containing a phosphorescent long-lived triplet energy donor (PD) and a NIR-II fluorescent energy acceptor (FA) by using phosphorescence resonance energy transfer (PRET) strategy. Because of the suitable spectral overlap of PD and FA, PRET NPs exhibit high NIR-II quantum yield in both normoxic and oxygen-free atmospheres. Based on that, in the in vivo tumor hypoxia imaging experiments, PRET NPs also exhibit high brightness and signal-to-background ratio (SBR) of NIR-II tumor-hypoxia imaging. Therefore, this study illustrates a general approach based on "PRET"strategy to develop bright NIR-II phosphorescent probes.
AB - Phosphorescence probes have emerged as a promising hypoxia detector for their excellent characters of long luminescence lifetime, large Stokes shift, and oxygen sensitivity. However, the low quantum yields of organic phosphorescence probes in the second near-infrared wavelength window (NIR-II, 1000-1700 nm) hinder their further development of NIR-II hypoxia imaging. Herein, this study reports a new NIR-II phosphorescence probe (PRET NPs) containing a phosphorescent long-lived triplet energy donor (PD) and a NIR-II fluorescent energy acceptor (FA) by using phosphorescence resonance energy transfer (PRET) strategy. Because of the suitable spectral overlap of PD and FA, PRET NPs exhibit high NIR-II quantum yield in both normoxic and oxygen-free atmospheres. Based on that, in the in vivo tumor hypoxia imaging experiments, PRET NPs also exhibit high brightness and signal-to-background ratio (SBR) of NIR-II tumor-hypoxia imaging. Therefore, this study illustrates a general approach based on "PRET"strategy to develop bright NIR-II phosphorescent probes.
UR - http://www.scopus.com/inward/record.url?scp=85143909631&partnerID=8YFLogxK
U2 - 10.1021/acsmaterialslett.2c01033
DO - 10.1021/acsmaterialslett.2c01033
M3 - Journal article
AN - SCOPUS:85143909631
SN - 2639-4979
VL - 5
SP - 116
EP - 124
JO - ACS Materials Letters
JF - ACS Materials Letters
IS - 1
ER -