Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Yun Ma; Shujun Zhang; Huanjie Wei; Yafang Dong; Liang Shen; Shujuan Liu; Qiang Zhao; Li Liu; Wai Yeung Wong

doi:10.1039/c8dt00720a

Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Yun Ma
, Shujun Zhang
, Huanjie Wei
, Yafang Dong
, Liang Shen
, Shujuan Liu
, Qiang Zhao
, Li Liu
, Wai Yeung Wong

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

22 Citations (Scopus)

Abstract

In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(iii) complex [Ir(L)(L′)] ³⁺ (PF ₆ ^- ) ₃ (C1) with L and L′ being terpyridine ligands (L = 4′-phenyl-2,2′:6′,2′′-terpyridine, L′ = 3-([2,2′:6′,2′′-terpyridin]-4′-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(iii) complex [Ir(dfppy) ₂ CN ₂ ] ^- Bu ₄ N ⁺ (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time.

Original language	English
Pages (from-to)	5582-5588
Number of pages	7
Journal	Dalton Transactions
Volume	47
Issue number	16
DOIs	https://doi.org/10.1039/c8dt00720a
Publication status	Published - 1 Jan 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Inorganic Chemistry

More information

10.1039/c8dt00720a

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@article{9c95fe76b4e24ac7a6672694873700f3,

title = "Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes",

abstract = " In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(iii) complex [Ir(L)(L′)] 3+ (PF 6 - ) 3 (C1) with L and L′ being terpyridine ligands (L = 4′-phenyl-2,2′:6′,2′′-terpyridine, L′ = 3-([2,2′:6′,2′′-terpyridin]-4′-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(iii) complex [Ir(dfppy) 2 CN 2 ] - Bu 4 N + (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time. ",

author = "Yun Ma and Shujun Zhang and Huanjie Wei and Yafang Dong and Liang Shen and Shujuan Liu and Qiang Zhao and Li Liu and Wong, \{Wai Yeung\}",

year = "2018",

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doi = "10.1039/c8dt00720a",

language = "English",

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journal = "Dalton Transactions",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

AU - Ma, Yun

AU - Zhang, Shujun

AU - Wei, Huanjie

AU - Dong, Yafang

AU - Shen, Liang

AU - Liu, Shujuan

AU - Zhao, Qiang

AU - Liu, Li

AU - Wong, Wai Yeung

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(iii) complex [Ir(L)(L′)] 3+ (PF 6 - ) 3 (C1) with L and L′ being terpyridine ligands (L = 4′-phenyl-2,2′:6′,2′′-terpyridine, L′ = 3-([2,2′:6′,2′′-terpyridin]-4′-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(iii) complex [Ir(dfppy) 2 CN 2 ] - Bu 4 N + (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time.

AB - In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(iii) complex [Ir(L)(L′)] 3+ (PF 6 - ) 3 (C1) with L and L′ being terpyridine ligands (L = 4′-phenyl-2,2′:6′,2′′-terpyridine, L′ = 3-([2,2′:6′,2′′-terpyridin]-4′-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(iii) complex [Ir(dfppy) 2 CN 2 ] - Bu 4 N + (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time.

UR - https://www.scopus.com/pages/publications/85045924771

U2 - 10.1039/c8dt00720a

DO - 10.1039/c8dt00720a

M3 - Journal article

C2 - 29649345

AN - SCOPUS:85045924771

SN - 1477-9226

VL - 47

SP - 5582

EP - 5588

JO - Dalton Transactions

JF - Dalton Transactions

IS - 16

ER -

Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Abstract

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