Enhanced Recognition Memory Following Glycine Transporter 1 Deletion in Forebrain Neurons

Philipp Singer, Detlev Boison, Hanns Möhler, Joram Feldon, Kay Yan Benjamin Yee

Research output: Journal article publicationJournal articleAcademic researchpeer-review

39 Citations (Scopus)

Abstract

Selective deletion of glycine transporter 1 (GlyT1) in forebrain neurons enhances N-methyl-d-aspartate receptor (NMDAR)-dependent neurotransmission and facilitates associative learning. These effects are attributable to increases in extracellular glycine availability in forebrain neurons due to reduced glycine re-uptake. Using a forebrain- and neuron-specific GlyT1-knockout mouse line (CamKIIαCre;GlyT1tm1.2fl/fI), the authors investigated whether this molecular intervention can affect recognition memory. In a spontaneous object recognition memory test, enhanced preference for a novel object was demonstrated in mutant mice relative to littermate control subjects at a retention interval of 2 hr, but not at 2 min. Furthermore, mutants were responsive to a switch in the relative spatial positions of objects, whereas control subjects were not. These potential procognitive effects were demonstrated against a lack of difference in contextual novelty detection: Mutant and control subjects showed equivalent preference for a novel over a familiar context. Results therefore extend the possible range of potential promnesic effects of specific forebrain neuronal GlyT1 deletion from associative learning to recognition memory and further support the possibility that mnemonic functions can be enhanced by reducing GlyT1 function.
Original languageEnglish
Pages (from-to)815-825
Number of pages11
JournalBehavioral Neuroscience
Volume121
Issue number5
DOIs
Publication statusPublished - 1 Oct 2007
Externally publishedYes

Keywords

  • cognitive enhancement
  • learning
  • mouse
  • NMDA receptor
  • object recognition

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

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