Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies

Shreya Goel; Feng Chen; Shijie Luan; Hector F. Valdovinos; Sixiang Shi; Stephen A. Graves; Fanrong Ai; Todd E. Barnhart; Charles P. Theuer; Weibo Cai

doi:10.1002/advs.201600122

Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies

Shreya Goel, Feng Chen, Shijie Luan, Hector F. Valdovinos, Sixiang Shi, Stephen A. Graves, Fanrong Ai, Todd E. Barnhart, Charles P. Theuer, Weibo Cai

Research output: Journal article publication › Journal article › Academic research › peer-review

68 Citations (Scopus)

Abstract

A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self-destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as-synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium-89 (⁸⁹Zr, t_1/2 = 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging. Rapid and persistent CD105 specific tumor vasculature targeting is successfully demonstrated in murine model of metastatic breast cancer by using TRC105 (an anti-CD105 antibody)-conjugated bMSNs. This study serves to illustrate a simple, versatile, and readily tunable approach to potentially overcome the current challenges facing nanomedicine and further the goals of personalized nanotheranostics.

Original language	English
Article number	1600122
Journal	Advanced Science
Volume	3
Issue number	11
Early online date	27 May 2016
DOIs	https://doi.org/10.1002/advs.201600122
Publication status	Published - Nov 2016
Externally published	Yes

Keywords

biodegradable mesoporous silica nanoparticles
intrinsic radiolabeling
positron emission tomography (PET) imaging
vasculature targeting

ASJC Scopus subject areas

Medicine (miscellaneous)
General Chemical Engineering
Biochemistry, Genetics and Molecular Biology (miscellaneous)
General Materials Science
General Engineering
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1002/advs.201600122

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Goel, S., Chen, F., Luan, S., Valdovinos, H. F., Shi, S., Graves, S. A., Ai, F., Barnhart, T. E., Theuer, C. P., & Cai, W. (2016). Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies. Advanced Science, 3(11), Article 1600122. https://doi.org/10.1002/advs.201600122

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abstract = "A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self-destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as-synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium-89 (89Zr, t1/2 = 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging. Rapid and persistent CD105 specific tumor vasculature targeting is successfully demonstrated in murine model of metastatic breast cancer by using TRC105 (an anti-CD105 antibody)-conjugated bMSNs. This study serves to illustrate a simple, versatile, and readily tunable approach to potentially overcome the current challenges facing nanomedicine and further the goals of personalized nanotheranostics.",

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AU - Valdovinos, Hector F.

AU - Shi, Sixiang

AU - Graves, Stephen A.

AU - Ai, Fanrong

AU - Barnhart, Todd E.

AU - Theuer, Charles P.

AU - Cai, Weibo

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AB - A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self-destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as-synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium-89 (89Zr, t1/2 = 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging. Rapid and persistent CD105 specific tumor vasculature targeting is successfully demonstrated in murine model of metastatic breast cancer by using TRC105 (an anti-CD105 antibody)-conjugated bMSNs. This study serves to illustrate a simple, versatile, and readily tunable approach to potentially overcome the current challenges facing nanomedicine and further the goals of personalized nanotheranostics.

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Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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