Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus

Xiaowei Tian; Tiantian Kong; Pingan Zhu; Zhanxiao Kang; Leyan Lei; Xin Tang; Liqiu Wang

doi:10.1016/j.ces.2018.02.040

Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus

Xiaowei Tian, Tiantian Kong, Pingan Zhu, Zhanxiao Kang, Leyan Lei, Xin Tang, Liqiu Wang

Research output: Journal article publication › Journal article › Academic research › peer-review

5 Citations (Scopus)

Abstract

A commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number B_E being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter d_d and its generation frequency f scale with the dimensionless controlling parameters in the form of d_d∼q^0.5, f∼q^-0.15B_E^0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties.

Original language	English
Pages (from-to)	13-19
Number of pages	7
Journal	Chemical Engineering Science
Volume	183
DOIs	https://doi.org/10.1016/j.ces.2018.02.040
Publication status	Published - 29 Jun 2018
Externally published	Yes

Keywords

Electrospray
Embolic microparticles
Micro-dripping mode
Pulsating meniscus

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Industrial and Manufacturing Engineering

More information

10.1016/j.ces.2018.02.040

Cite this

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title = "Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus",

abstract = "A commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter dd and its generation frequency f scale with the dimensionless controlling parameters in the form of dd∼q0.5, f∼q-0.15BE0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties.",

keywords = "Electrospray, Embolic microparticles, Micro-dripping mode, Pulsating meniscus",

author = "Xiaowei Tian and Tiantian Kong and Pingan Zhu and Zhanxiao Kang and Leyan Lei and Xin Tang and Liqiu Wang",

note = "Funding Information: Authors wish to thank the financial support from the Research Grants Council of Hong Kong ( GRF 17237316 , 17211115 , 17207914 , HKU717613E ), the University of Hong Kong ( URC 201511159108 , 201411159074 and 201311159187 ), the National Natural Science Foundation of China (Young Scholar{\textquoteright}s Program NSFC 11504238 ), the Science and Technology Planning Project of Guangdong Province ( 2016A050503048 ), and the Fundamental Research Program of Shenzhen ( JCYJ20160229164007864 ). The work is also supported in part by the Zhejiang Provincial, Hangzhou Municipal and Lin{\textquoteright}an County Governments. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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doi = "10.1016/j.ces.2018.02.040",

language = "English",

volume = "183",

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AU - Tian, Xiaowei

AU - Kong, Tiantian

AU - Zhu, Pingan

AU - Kang, Zhanxiao

AU - Lei, Leyan

AU - Tang, Xin

AU - Wang, Liqiu

N1 - Funding Information: Authors wish to thank the financial support from the Research Grants Council of Hong Kong ( GRF 17237316 , 17211115 , 17207914 , HKU717613E ), the University of Hong Kong ( URC 201511159108 , 201411159074 and 201311159187 ), the National Natural Science Foundation of China (Young Scholar’s Program NSFC 11504238 ), the Science and Technology Planning Project of Guangdong Province ( 2016A050503048 ), and the Fundamental Research Program of Shenzhen ( JCYJ20160229164007864 ). The work is also supported in part by the Zhejiang Provincial, Hangzhou Municipal and Lin’an County Governments. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/6/29

Y1 - 2018/6/29

N2 - A commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter dd and its generation frequency f scale with the dimensionless controlling parameters in the form of dd∼q0.5, f∼q-0.15BE0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties.

AB - A commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter dd and its generation frequency f scale with the dimensionless controlling parameters in the form of dd∼q0.5, f∼q-0.15BE0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties.

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KW - Embolic microparticles

KW - Micro-dripping mode

KW - Pulsating meniscus

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Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus

Abstract

Keywords

ASJC Scopus subject areas

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