Engineering Advanced Dynamic Biomaterials to Optimize Adoptive T-cell Immunotherapy

Wai Ki Wong, Bohan Yin, Anel Rakhmatullina, Jingying Zhou (Corresponding Author), Siu Hong Wong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the tumor. The outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells, which provides signals for generating different T-cell phenotypes with different roles in tumor removal. However, such interaction is often not optimal in vivo and results in low therapeutic efficacy. To reach the full potential of the T-cell response, current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell fate. In this perspective, we provide (1) an overview of ACT and general T-cells behaviors, (2) explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors, (3) and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy.
Original languageEnglish
Article number2
Pages (from-to)70-81
Number of pages12
JournalEngineered Regeneration
Volume2
Publication statusPublished - 11 Jun 2021

Keywords

  • T-cell mechanobiology
  • Dynamic nanobiomaterials
  • Adoptive T-cell immunotherapy
  • Ligand presentation

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