Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer

Zhiming Deng; Mingyang Jiang; Youbin Li; Hongrong Liu; Songjun Zeng; Jianhua Hao

doi:10.1016/j.isci.2019.06.034

Endogenous H₂S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer

Zhiming Deng
, Mingyang Jiang
, Youbin Li
, Hongrong Liu
, Songjun Zeng
, Jianhua Hao

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

46 Citations (Scopus)

Abstract

Overexpression of endogenous H₂S is one of the key characteristic in colon cancer. However, developing endogenous H₂S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H₂S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000–1,400 nm via endogenous H₂S-induced in situ chemical reaction to form Ag₂S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H₂S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.

Original language	English
Pages (from-to)	217-224
Number of pages	8
Journal	iScience
Volume	17
DOIs	https://doi.org/10.1016/j.isci.2019.06.034
Publication status	Published - 26 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomolecules
Cancer
Optical Imaging

ASJC Scopus subject areas

General

More information

10.1016/j.isci.2019.06.034

http://hdl.handle.net/10397/81324

Cite this

@article{b55d983471574172b758484b0315b958,

title = "Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer",

abstract = "Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000{\textendash}1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.",

keywords = "Biomolecules, Cancer, Optical Imaging",

author = "Zhiming Deng and Mingyang Jiang and Youbin Li and Hongrong Liu and Songjun Zeng and Jianhua Hao",

year = "2019",

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doi = "10.1016/j.isci.2019.06.034",

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journal = "iScience",

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T1 - Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer

AU - Deng, Zhiming

AU - Jiang, Mingyang

AU - Li, Youbin

AU - Liu, Hongrong

AU - Zeng, Songjun

AU - Hao, Jianhua

PY - 2019/7/26

Y1 - 2019/7/26

N2 - Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000–1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.

AB - Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000–1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.

KW - Biomolecules

KW - Cancer

KW - Optical Imaging

UR - https://www.scopus.com/pages/publications/85068569872

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DO - 10.1016/j.isci.2019.06.034

M3 - Journal article

AN - SCOPUS:85068569872

SN - 2589-0042

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JO - iScience

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