Sketch-based face recognition is an interesting task in vision and multimedia research, yet it is quite challenging due to the great difference between face photos and sketches. In this paper, we propose a novel approach for photo-sketch generation, aiming to automatically transform face photos into detail-preserving personal sketches. Unlike the traditional models synthesizing sketches based on a dictionary of exemplars, we develop a fully convolutional network to learn the end-to-end photo-sketch mapping. Our approach takes whole face photos as inputs and directly generates the corresponding sketch images with efficient inference and learning, in which the architecture is stacked by only convolutional kernels of very small sizes. To well capture the person identity during the photo-sketch transformation, we define our optimization objective in the form of joint generativediscriminative minimization. In particular, a discriminative regularization term is incorporated into the photo-sketch generation, enhancing the discriminability of the generated person sketches against other individuals. Extensive experiments on several standard benchmarks suggest that our approach outperforms other state-of-the-arts in both photosketch generation and face sketch verification.