An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful.
|Number of pages||16|
|Journal||Collection of Czechoslovak Chemical Communications|
|Publication status||Published - 1 Dec 2011|
- Shapiro reaction
- Synthesis design
- Wieland-Miescher ketone
ASJC Scopus subject areas