Abstract
An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful.
| Original language | English |
|---|---|
| Pages (from-to) | 1579-1594 |
| Number of pages | 16 |
| Journal | Collection of Czechoslovak Chemical Communications |
| Volume | 76 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2011 |
| Externally published | Yes |
Keywords
- Ozonolysis
- Shapiro reaction
- Synthesis design
- Taxol
- Terpenoids
- Wieland-Miescher ketone
ASJC Scopus subject areas
- General Chemistry