Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities

Stanton Hon Lung Kok, Wing Sze Lam, Albert Sun Chi Chan, Wai Yeung Wong, Roberto Gambari, Raymond Siu Ming Wong, Kenneth Ka Ho Lee, Cheuk On Tang, Kim Hung Lam, Chung Hin Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

In connection to our previously reported phosphine compounds as antitumor agents, this article describes the preparation of ferrocenyl amino-phosphine and their possible cytotoxic potential towards the human hepatocellular carcinoma cell line Hep3B. The preliminary results suggested that ferrocenyl amino-phosphines can be potential anti-tumour agents which might be considered as novel cancer chemotherapeutic agents. In particular, compounds 4b, 4d and 4f exhibit strong cytotoxicity with IC50< 5 μg ml-1. These compounds possess more promising cytotoxic activities than their precursor non-substituted ferrocene as well as the reference metallodrug cisplatin.
Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalMedChemComm
Volume2
Issue number9
DOIs
Publication statusPublished - 1 Sep 2011

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

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