Chiral ferrocenyl heterobidentate P/S ligands bearing both central and planar chirality were prepared from (S)-ugi's amine via a three-step modular synthesis. Through systematic screening and optimization, L8 was found to be the best ligand for Pd-catalyzed asymmetric allylic alkylation of indoles with ee's up to 96% being attained.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry