Enantioselective Pd-catalyzed allylic alkylation of indoles by a new class of chiral ferrocenyl P/S ligands

Hong Yee Cheung, Wing Yiu Yu, Fuk Loi Lam, Terry T.L. Au-Yeung, Zhongyuan Zhou, Tak Hang Chan, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

105 Citations (Scopus)

Abstract

Chiral ferrocenyl heterobidentate P/S ligands bearing both central and planar chirality were prepared from (S)-ugi's amine via a three-step modular synthesis. Through systematic screening and optimization, L8 was found to be the best ligand for Pd-catalyzed asymmetric allylic alkylation of indoles with ee's up to 96% being attained.
Original languageEnglish
Pages (from-to)4295-4298
Number of pages4
JournalOrganic Letters
Volume9
Issue number21
DOIs
Publication statusPublished - 11 Oct 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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