Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: Linking environmental cues to microRNAs

Hsiao Chang Chan, Xiaohua Jiang, Yechun Ruan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Although microRNAs (miRNAs) have been recognized as one of the important epigenetic mechanisms that regulate gene expression in response to changes in the environment, the links between environmental cues and changes in miRNAs remain largely unknown. Localized to the cell membrane and recognized as an anion channel, the cystic fibrosis transmembrane conductance regulator (CFTR) has recently been shown to mediate important signalling pathways leading to activation of miRNAs. This brief review summarizes the related findings and discusses the emerging role of CFTR as an epigenetic regulator, possibly involved in a wide spectrum of physiological and pathological processes.
Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume41
Issue number9
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Cystic fibrosis transmembrane conductance regulator
  • Epigenetic regulation
  • MicroRNAs

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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