Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China

Rong Zhang; Dachuan Lin; Edward Wai Chi Chan; Danxia Gu; Gong Xiang Chen; Sheng Chen

doi:10.1128/AAC.02173-15

Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China

Rong Zhang, Dachuan Lin, Edward Wai Chi Chan, Danxia Gu, Gong Xiang Chen, Sheng Chen

Research output: Journal article publication › Journal article › Academic research › peer-review

184 Citations (Scopus)

Abstract

We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne blaKPC-2gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.

Original language	English
Pages (from-to)	709-711
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	1
DOIs	https://doi.org/10.1128/AAC.02173-15
Publication status	Published - 1 Jan 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02173-15

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abstract = "We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne blaKPC-2gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.",

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AU - Gu, Danxia

AU - Chen, Gong Xiang

AU - Chen, Sheng

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AB - We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne blaKPC-2gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.

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Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China

Abstract

ASJC Scopus subject areas

UN SDGs

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