Emergence of carbapenem-resistant acinetobacter baumannii ST195 Harboring blaOXA-23 isolated from bacteremia in Hong Kong

Eddie Chi Man Leung; Polly Hang Mei Leung; Raymond Wai Man Lai

doi:10.1089/mdr.2018.0433

Emergence of carbapenem-resistant acinetobacter baumannii ST195 Harboring bla_OXA-23 isolated from bacteremia in Hong Kong

Eddie Chi Man Leung
, Polly Hang Mei Leung
, Raymond Wai Man Lai

Research output: Journal article publication › Journal article › Academic research › peer-review

10 Citations (Scopus)

Abstract

Aims: The aim of the study was to analyze the epidemiology of Acinetobacter baumannii and investigate the genetic characteristics of carbapenem-resistant A. baumannii (CRAB) isolates isolated from blood cultures in a regional hospital in Hong Kong. Results: Twenty blood culture isolates were collected from a regional hospital in Hong Kong from 2014 to 2017. Twenty isolates were grouped into five existing sequence types (STs) and five new STs within the following prevalence: ST195 was predominant with a prevalence of 45% (n = 9), followed by ST373 and ST447 (10%; n = 2 each), and ST176 and ST345 (5%; n = 1 each). Resistance to carbapenem antibiotics was 55% (n = 11). Six carbapenem-resistant isolates harbored bla_OXA-23 genes and ISAba1 mobile elements. Polymerase chain reaction confirmed that ISAba1 is located upstream to the bla_OXA-23 genes, suggesting an association between ISAba1 and bla_OXA-23 genes with carbapenem resistance. Conclusion: This study is the first to report the emergence of CRAB ST195 harboring bla_OXA-23 in Hong Kong.

Original language	English
Pages (from-to)	1199-1203
Number of pages	5
Journal	Microbial Drug Resistance
Volume	25
Issue number	8
Early online date	Jun 2019
DOIs	https://doi.org/10.1089/mdr.2018.0433
Publication status	Published - 11 Oct 2019

Keywords

Acinetobacter baumannii
carbapenemase genes
multilocus sequence typing
ST195

ASJC Scopus subject areas

Microbiology
Immunology
Pharmacology
Microbiology (medical)

More information

10.1089/mdr.2018.0433

Cite this

@article{9ea10a6c506844659a8d1a3b1e99f520,

title = "Emergence of carbapenem-resistant acinetobacter baumannii ST195 Harboring blaOXA-23 isolated from bacteremia in Hong Kong",

abstract = "Aims: The aim of the study was to analyze the epidemiology of Acinetobacter baumannii and investigate the genetic characteristics of carbapenem-resistant A. baumannii (CRAB) isolates isolated from blood cultures in a regional hospital in Hong Kong. Results: Twenty blood culture isolates were collected from a regional hospital in Hong Kong from 2014 to 2017. Twenty isolates were grouped into five existing sequence types (STs) and five new STs within the following prevalence: ST195 was predominant with a prevalence of 45\% (n = 9), followed by ST373 and ST447 (10\%; n = 2 each), and ST176 and ST345 (5\%; n = 1 each). Resistance to carbapenem antibiotics was 55\% (n = 11). Six carbapenem-resistant isolates harbored blaOXA-23 genes and ISAba1 mobile elements. Polymerase chain reaction confirmed that ISAba1 is located upstream to the blaOXA-23 genes, suggesting an association between ISAba1 and blaOXA-23 genes with carbapenem resistance. Conclusion: This study is the first to report the emergence of CRAB ST195 harboring blaOXA-23 in Hong Kong.",

keywords = "Acinetobacter baumannii, carbapenemase genes, multilocus sequence typing, ST195",

author = "Leung, \{Eddie Chi Man\} and Leung, \{Polly Hang Mei\} and Lai, \{Raymond Wai Man\}",

year = "2019",

month = oct,

day = "11",

doi = "10.1089/mdr.2018.0433",

language = "English",

volume = "25",

pages = "1199--1203",

journal = "Microbial Drug Resistance",

issn = "1076-6294",

publisher = "Mary Ann Liebert Inc.",

number = "8",

}

TY - JOUR

T1 - Emergence of carbapenem-resistant acinetobacter baumannii ST195 Harboring blaOXA-23 isolated from bacteremia in Hong Kong

AU - Leung, Eddie Chi Man

AU - Leung, Polly Hang Mei

AU - Lai, Raymond Wai Man

PY - 2019/10/11

Y1 - 2019/10/11

N2 - Aims: The aim of the study was to analyze the epidemiology of Acinetobacter baumannii and investigate the genetic characteristics of carbapenem-resistant A. baumannii (CRAB) isolates isolated from blood cultures in a regional hospital in Hong Kong. Results: Twenty blood culture isolates were collected from a regional hospital in Hong Kong from 2014 to 2017. Twenty isolates were grouped into five existing sequence types (STs) and five new STs within the following prevalence: ST195 was predominant with a prevalence of 45% (n = 9), followed by ST373 and ST447 (10%; n = 2 each), and ST176 and ST345 (5%; n = 1 each). Resistance to carbapenem antibiotics was 55% (n = 11). Six carbapenem-resistant isolates harbored blaOXA-23 genes and ISAba1 mobile elements. Polymerase chain reaction confirmed that ISAba1 is located upstream to the blaOXA-23 genes, suggesting an association between ISAba1 and blaOXA-23 genes with carbapenem resistance. Conclusion: This study is the first to report the emergence of CRAB ST195 harboring blaOXA-23 in Hong Kong.

AB - Aims: The aim of the study was to analyze the epidemiology of Acinetobacter baumannii and investigate the genetic characteristics of carbapenem-resistant A. baumannii (CRAB) isolates isolated from blood cultures in a regional hospital in Hong Kong. Results: Twenty blood culture isolates were collected from a regional hospital in Hong Kong from 2014 to 2017. Twenty isolates were grouped into five existing sequence types (STs) and five new STs within the following prevalence: ST195 was predominant with a prevalence of 45% (n = 9), followed by ST373 and ST447 (10%; n = 2 each), and ST176 and ST345 (5%; n = 1 each). Resistance to carbapenem antibiotics was 55% (n = 11). Six carbapenem-resistant isolates harbored blaOXA-23 genes and ISAba1 mobile elements. Polymerase chain reaction confirmed that ISAba1 is located upstream to the blaOXA-23 genes, suggesting an association between ISAba1 and blaOXA-23 genes with carbapenem resistance. Conclusion: This study is the first to report the emergence of CRAB ST195 harboring blaOXA-23 in Hong Kong.

KW - Acinetobacter baumannii

KW - carbapenemase genes

KW - multilocus sequence typing

KW - ST195

UR - https://www.scopus.com/pages/publications/85073183196

U2 - 10.1089/mdr.2018.0433

DO - 10.1089/mdr.2018.0433

M3 - Journal article

C2 - 31158046

AN - SCOPUS:85073183196

SN - 1076-6294

VL - 25

SP - 1199

EP - 1203

JO - Microbial Drug Resistance

JF - Microbial Drug Resistance

IS - 8

ER -