Emergence of carbapenem-resistant acinetobacter baumannii ST195 Harboring blaOXA-23 isolated from bacteremia in Hong Kong

Eddie Chi Man Leung, Polly Hang Mei Leung, Raymond Wai Man Lai

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

Aims: The aim of the study was to analyze the epidemiology of Acinetobacter baumannii and investigate the genetic characteristics of carbapenem-resistant A. baumannii (CRAB) isolates isolated from blood cultures in a regional hospital in Hong Kong. Results: Twenty blood culture isolates were collected from a regional hospital in Hong Kong from 2014 to 2017. Twenty isolates were grouped into five existing sequence types (STs) and five new STs within the following prevalence: ST195 was predominant with a prevalence of 45% (n = 9), followed by ST373 and ST447 (10%; n = 2 each), and ST176 and ST345 (5%; n = 1 each). Resistance to carbapenem antibiotics was 55% (n = 11). Six carbapenem-resistant isolates harbored blaOXA-23 genes and ISAba1 mobile elements. Polymerase chain reaction confirmed that ISAba1 is located upstream to the blaOXA-23 genes, suggesting an association between ISAba1 and blaOXA-23 genes with carbapenem resistance. Conclusion: This study is the first to report the emergence of CRAB ST195 harboring blaOXA-23 in Hong Kong.

Original languageEnglish
Pages (from-to)1199-1203
Number of pages5
JournalMicrobial Drug Resistance
Volume25
Issue number8
Early online dateJun 2019
DOIs
Publication statusPublished - 11 Oct 2019

Keywords

  • Acinetobacter baumannii
  • carbapenemase genes
  • multilocus sequence typing
  • ST195

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

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