Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications

Qiang Zhang; Yingchun Li; Zhi Yuan (William) Lin; Kenneth K.Y. Wong; Min Lin; Lara Yildirimer; Xin Zhao

doi:10.1016/j.drudis.2017.05.007

Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications

Qiang Zhang
, Yingchun Li
, Zhi Yuan (William) Lin
, Kenneth K.Y. Wong
, Min Lin
, Lara Yildirimer
, Xin Zhao

Research output: Journal article publication › Review article › Academic research › peer-review

141 Citations (Scopus)

Abstract

Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.

Original language	English
Pages (from-to)	1351-1366
Number of pages	16
Journal	Drug Discovery Today
Volume	22
Issue number	9
DOIs	https://doi.org/10.1016/j.drudis.2017.05.007
Publication status	Published - 1 Sept 2017

ASJC Scopus subject areas

Pharmacology
Drug Discovery

More information

10.1016/j.drudis.2017.05.007

http://hdl.handle.net/10397/70452

Cite this

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abstract = "Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.",

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AU - Zhang, Qiang

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AU - Lin, Zhi Yuan (William)

AU - Wong, Kenneth K.Y.

AU - Lin, Min

AU - Yildirimer, Lara

AU - Zhao, Xin

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.

AB - Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.

UR - https://www.scopus.com/pages/publications/85020913160

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DO - 10.1016/j.drudis.2017.05.007

M3 - Review article

C2 - 28552498

SN - 1359-6446

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JO - Drug Discovery Today

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Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications

Abstract

ASJC Scopus subject areas

More information

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