Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications

Qiang Zhang, Yingchun Li, Zhi Yuan (William) Lin, Kenneth K.Y. Wong, Min Lin, Lara Yildirimer, Xin Zhao

Research output: Journal article publicationReview articleAcademic researchpeer-review

54 Citations (Scopus)

Abstract

Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.
Original languageEnglish
Pages (from-to)1351-1366
Number of pages16
JournalDrug Discovery Today
Volume22
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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