TY - JOUR
T1 - Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications
AU - Zhang, Qiang
AU - Li, Yingchun
AU - Lin, Zhi Yuan (William)
AU - Wong, Kenneth K.Y.
AU - Lin, Min
AU - Yildirimer, Lara
AU - Zhao, Xin
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.
AB - Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.
UR - http://www.scopus.com/inward/record.url?scp=85020913160&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2017.05.007
DO - 10.1016/j.drudis.2017.05.007
M3 - Review article
C2 - 28552498
SN - 1359-6446
VL - 22
SP - 1351
EP - 1366
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 9
ER -