Abstract
Cardiac tissue engineering has evolved as a potential therapeutic approach to assist cardiac regeneration. Controlling the preferential cell orientation of engineered heart tissues is a key issue in cardiac tissue engineering. Here, we present a novel method to construct a model-engineered cardiac tissue-like structure with anisotropic properties. Our analysis shows that the electro-torque which acts on a cylindrical or rod shape cell is zero whenever the electric field is aligned with one of its principal axes. With the interdigitated-castellated microelectrodes, the induction of dielectrophoresis and electro-orientation can accumulate cells and form a tissue-like structure with orientation along the ac electric field. Both experiments and analysis indicate that a large orientation torque and force can be achieved with appropriate frequency and low conductive medium. Finally, we report basic structural and biophysical anisotropy of electro-oriented structure through electromechanical experiments.
Original language | English |
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Pages (from-to) | 73-79 |
Number of pages | 7 |
Journal | Sensors and Actuators, A: Physical |
Volume | 135 |
Issue number | 1 |
DOIs | |
Publication status | Published - 30 Mar 2007 |
Keywords
- Controlled anisotropy
- Dielectrophoresis
- Electro-orientation
- Microfluidic chip
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering