Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Teris Cheung; Benjamin K. Yee; Bolton Chau; Joyce Yuen Ting Lam; Kwan Hin Fong; Herman Lo; Tim Man Ho Li; Albert Martin Li; Lei Sun; Roland Beisteiner; Calvin Pak Wing Cheng

doi:10.3389/fneur.2024.1364270

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Teris Cheung (Corresponding Author), Benjamin K. Yee, Bolton Chau, Joyce Yuen Ting Lam, Kwan Hin Fong, Herman Lo, Tim Man Ho Li, Albert Martin Li, Lei Sun, Roland Beisteiner, Calvin Pak Wing Cheng (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

Background: This is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong. Methods: This double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data. Results: The TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups. Conclusion: TPS is an effective and safe adjunct treatment for the clinical management of ADHD. Clinical trial registration: ClinicalTrials.Gov, identifier NCT05422274.

Original language	English
Article number	1364270
Pages (from-to)	1-16
Number of pages	16
Journal	Frontiers in Neurology
Volume	15
DOIs	https://doi.org/10.3389/fneur.2024.1364270
Publication status	Published - 9 May 2024

Keywords

ADHD
adolescents
efficacy
neuromodulation
rct
transcranial pulse stimulation

ASJC Scopus subject areas

Neurology
Clinical Neurology

More information

10.3389/fneur.2024.1364270

Cite this

Cheung, T., Yee, B. K., Chau, B., Lam, J. Y. T., Fong, K. H., Lo, H., Li, T. M. H., Li, A. M., Sun, L., Beisteiner, R., & Cheng, C. P. W. (2024). Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial. Frontiers in Neurology, 15, 1-16. Article 1364270. https://doi.org/10.3389/fneur.2024.1364270

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title = "Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial",

abstract = "Background: This is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong. Methods: This double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data. Results: The TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups. Conclusion: TPS is an effective and safe adjunct treatment for the clinical management of ADHD. Clinical trial registration: ClinicalTrials.Gov, identifier NCT05422274.",

keywords = "ADHD, adolescents, efficacy, neuromodulation, rct, transcranial pulse stimulation",

author = "Teris Cheung and Yee, {Benjamin K.} and Bolton Chau and Lam, {Joyce Yuen Ting} and Fong, {Kwan Hin} and Herman Lo and Li, {Tim Man Ho} and Li, {Albert Martin} and Lei Sun and Roland Beisteiner and Cheng, {Calvin Pak Wing}",

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year = "2024",

month = may,

day = "9",

doi = "10.3389/fneur.2024.1364270",

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Cheung, T , Yee, BK , Chau, B, Lam, JYT, Fong, KH, Lo, H, Li, TMH, Li, AM, Sun, L, Beisteiner, R & Cheng, CPW 2024, 'Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial', Frontiers in Neurology, vol. 15, 1364270, pp. 1-16. https://doi.org/10.3389/fneur.2024.1364270

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial. / Cheung, Teris (Corresponding Author); Yee, Benjamin K.; Chau, Bolton et al.
In: Frontiers in Neurology, Vol. 15, 1364270, 09.05.2024, p. 1-16.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Cheung, Teris

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AU - Chau, Bolton

AU - Lam, Joyce Yuen Ting

AU - Fong, Kwan Hin

AU - Lo, Herman

AU - Li, Tim Man Ho

AU - Li, Albert Martin

AU - Sun, Lei

AU - Beisteiner, Roland

AU - Cheng, Calvin Pak Wing

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Y1 - 2024/5/9

N2 - Background: This is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong. Methods: This double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data. Results: The TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups. Conclusion: TPS is an effective and safe adjunct treatment for the clinical management of ADHD. Clinical trial registration: ClinicalTrials.Gov, identifier NCT05422274.

AB - Background: This is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong. Methods: This double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data. Results: The TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups. Conclusion: TPS is an effective and safe adjunct treatment for the clinical management of ADHD. Clinical trial registration: ClinicalTrials.Gov, identifier NCT05422274.

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DO - 10.3389/fneur.2024.1364270

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AN - SCOPUS:85193861683

SN - 1664-2295

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SP - 1

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JO - Frontiers in Neurology

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M1 - 1364270

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Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Abstract

Keywords

ASJC Scopus subject areas

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