Effects of whole body vibration on prevention of bone loss in 8-week tail-suspended male rats

Cheng Tan, Wei Su, Chao Ma, Zhili Li, Huijuan Wang, Wenjuan Chen, Zheng Ke, Ming Zhang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

2 Citations (Scopus)


Objective: To investigate the effects of low frequency whole body vibration on preventing the bone loss of rats' lower limbs induced by tail suspended. Method: 40 male rats were divided randomly into 4 groups, including tail suspended group(sus, n=10), tail suspended + ground stimulus group (s+g, ground stimulus: 30min/d, 5d/w, n=10), tail suspended + vibration group (s+v, vibration stimulus: 45Hz, 0.2-0.5g, 30min/d, 5d/w, n=10), and control group (con, n=10). Bone mineral density (BMD) of femur, trabecular structure in femur head, and the concentration of bone formation and resorption markers (Ca, P, ALP, BALP, PICP-1, TRACP ) in serum were tested after 8 weeks experiment. The tibias were taken to experiencing the 3-point bending test to explore the anti-load ability changes. Result: After 8 weeks tail suspended, the BMD of femur head (mainly trabecular bone) in s+v group were significantly higher than that in sus and s+g group, but lower than con group(P<0.05). But the BMD of middle femur (mainly cortical bone) had no great changes between groups. The trabecular structure parameter (BVF%, Tb.Th) in s+v group were also higher than sus and s+g group(P<0.05), and with no difference with con group(P>0.05). The max load and stiffness of tibia in con group were higher than that in sus, s+g and s+v group, but it had no statistical difference among the latter three groups (P>0.05). There were no changes of the concentration of bone formation and resorption markers in serum between groups. Conclusion: 45Hz whole body vibration could prevent the trabecular bone loss induced by tail suspended, but not the cortical bone. It seems that the benefit of whole body vibration to totally prevent the bone loss during long-duration space flight is limited.
Original languageEnglish
Title of host publicationProceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010
Number of pages4
Publication statusPublished - 1 Dec 2010
Event3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010 - Yantai, China
Duration: 16 Oct 201018 Oct 2010


Conference3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010


  • Bone loss
  • Countermeasure
  • Low frequency whole body vibration
  • Muscle atrophy
  • Space flight

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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