TY - JOUR
T1 - Effects of virtual reality in post-stroke aphasia
T2 - a systematic review and meta-analysis
AU - Cao, Yun
AU - Huang, Xing
AU - Zhang, Binlong
AU - Kranz, Georg S.
AU - Zhang, Danli
AU - Li, Xiaolin
AU - Chang, Jingling
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (grant number 81973790) and the Beijing Municipal Natural Science Foundation (grant number 7181005).
Publisher Copyright:
© 2021, Fondazione Società Italiana di Neurologia.
PY - 2021/4/9
Y1 - 2021/4/9
N2 - Objective: To investigate whether virtual reality (VR) interventions have beneficial effects on the functional communication and language function of patients with post-stroke aphasia (PSA). Methods: We searched nine electronic literature databases and two clinical registry platforms to identify randomized controlled trials (RCTs) and quasi-RCTs performed up to September 2020. Screening, quality assessment, and data collection were performed by two authors independently, using standard protocols. Data aggregation and risk of bias evaluation were conducted using Review Manager Version 5.4. The quality of evidence was evaluated with GRADEpro. Results: A total of five studies involving 121 participants met the inclusion criteria and were appraised. Four studies were included in the quantitative synthesis. VR reduced the severity of language impairment with borderline significance [SMD (95%CI) = 0.70[0.01, 1.39], P=0.05]. The meta-analysis showed no statistical difference in functional communication [SMD (95%CI) =0.41[−0.29, 1.12], P=0.25], word finding [SMD (95%CI) =0.42[−0.24, 1.08], P=0.21], and repetition [SMD (95%CI) =0.16[−0.62, 0.94], P=0.68] between VR group and the control group. Conclusion: This review demonstrated a borderline positive clinical effect of VR for the severity of language impairment when compared with conventional rehabilitation therapy. Conversely, VR had no effect on functional communication, word finding, and repetition. Further research is warranted to reach more definite conclusions.
AB - Objective: To investigate whether virtual reality (VR) interventions have beneficial effects on the functional communication and language function of patients with post-stroke aphasia (PSA). Methods: We searched nine electronic literature databases and two clinical registry platforms to identify randomized controlled trials (RCTs) and quasi-RCTs performed up to September 2020. Screening, quality assessment, and data collection were performed by two authors independently, using standard protocols. Data aggregation and risk of bias evaluation were conducted using Review Manager Version 5.4. The quality of evidence was evaluated with GRADEpro. Results: A total of five studies involving 121 participants met the inclusion criteria and were appraised. Four studies were included in the quantitative synthesis. VR reduced the severity of language impairment with borderline significance [SMD (95%CI) = 0.70[0.01, 1.39], P=0.05]. The meta-analysis showed no statistical difference in functional communication [SMD (95%CI) =0.41[−0.29, 1.12], P=0.25], word finding [SMD (95%CI) =0.42[−0.24, 1.08], P=0.21], and repetition [SMD (95%CI) =0.16[−0.62, 0.94], P=0.68] between VR group and the control group. Conclusion: This review demonstrated a borderline positive clinical effect of VR for the severity of language impairment when compared with conventional rehabilitation therapy. Conversely, VR had no effect on functional communication, word finding, and repetition. Further research is warranted to reach more definite conclusions.
KW - Aphasia
KW - Meta-analysis
KW - Rehabilitation
KW - Systematic review
KW - Virtual reality
UR - http://www.scopus.com/inward/record.url?scp=85104051245&partnerID=8YFLogxK
U2 - 10.1007/s10072-021-05202-5
DO - 10.1007/s10072-021-05202-5
M3 - Journal article
AN - SCOPUS:85104051245
SN - 1590-1874
VL - 42
SP - 5249
EP - 5259
JO - Neurological Sciences
JF - Neurological Sciences
IS - 12
ER -
