TY - JOUR
T1 - Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression—A Pilot Randomized Controlled Trial
AU - Cheung, Teris
AU - Li, Tim Man Ho
AU - Ho, Yuen Shan
AU - Kranz, Georg
AU - Fong, Kenneth N.K.
AU - Leung, Sau Fong
AU - Lam, Simon Ching
AU - Yeung, Wing Fai
AU - Lam, Joyce Yuen Ting
AU - Fong, Kwan Hin
AU - Beisteiner, Roland
AU - Xiang, Yu Tao
AU - Cheng, Calvin Pak Wing
N1 - Funding Information:
This research was funded by the Department General Research Fund and the Hong Kong Polytechnic University, Hong Kong (reference #: P0036773). Roland Beisteiner received research grants and laboratory support from the Medical University of Vienna and University of Vienna (SO10300020), Austrian Science Fund (FWF KLIF455), STORZ Medical AG and Herzfelder’sche Familienstiftung.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain stimulations (NIBS) that has been proven to be effective in terms of significantly improving Alzheimer patients’ cognition, memory, and execution functions. Nonetheless, there is, currently, no trial evaluating the efficacy of TPS on adults with major depression disorder (MDD) nationwide. In this single-blinded, randomized controlled trial, a 2-week TPS treatment comprising six 30 min TPS sessions were administered to participants. Participants were randomized into either the TPS group or the Waitlist Control (WC) group, stratified by gender and age according to a 1:1 ratio. Our primary outcome was evaluated by the Hamilton depression rating scale-17 (HDRS-17). We recruited 30 participants that were aged between 18 and 54 years, predominantly female (73%), and ethnic Chinese from 1 August to 31 October 2021. Moreover, there was a significant group x time interaction (F(1, 28) = 18.8, p < 0.001). Further, when compared with the WC group, there was a significant reduction in the depressive symptom severity in the TPS group (mean difference = −6.60, p = 0.02, and Cohen’s d = −0.93). The results showed a significant intervention effect; in addition, the effect was large and sustainable at the 3-month follow-up. In this trial, it was found that TPS is effective in reducing depressive symptoms among adults with MDD.
AB - Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain stimulations (NIBS) that has been proven to be effective in terms of significantly improving Alzheimer patients’ cognition, memory, and execution functions. Nonetheless, there is, currently, no trial evaluating the efficacy of TPS on adults with major depression disorder (MDD) nationwide. In this single-blinded, randomized controlled trial, a 2-week TPS treatment comprising six 30 min TPS sessions were administered to participants. Participants were randomized into either the TPS group or the Waitlist Control (WC) group, stratified by gender and age according to a 1:1 ratio. Our primary outcome was evaluated by the Hamilton depression rating scale-17 (HDRS-17). We recruited 30 participants that were aged between 18 and 54 years, predominantly female (73%), and ethnic Chinese from 1 August to 31 October 2021. Moreover, there was a significant group x time interaction (F(1, 28) = 18.8, p < 0.001). Further, when compared with the WC group, there was a significant reduction in the depressive symptom severity in the TPS group (mean difference = −6.60, p = 0.02, and Cohen’s d = −0.93). The results showed a significant intervention effect; in addition, the effect was large and sustainable at the 3-month follow-up. In this trial, it was found that TPS is effective in reducing depressive symptoms among adults with MDD.
KW - efficacy
KW - major depressive disorder
KW - noninvasive brain stimulation
KW - transcranial pulse stimulation
UR - http://www.scopus.com/inward/record.url?scp=85147895404&partnerID=8YFLogxK
U2 - 10.3390/ijerph20032333
DO - 10.3390/ijerph20032333
M3 - Journal article
C2 - 36767702
AN - SCOPUS:85147895404
SN - 1661-7827
VL - 20
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 3
M1 - 2333
ER -