Effects of fatty acids on growth and Poly-3-hydroxybutyrate production in bacteria

K. W. Lo, H. Chua, H. Lawford, Wai Hung Lo, Peter H.F. Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

19 Citations (Scopus)


The effects of saturated and unsaturated fatty acids (lauric acid, palmitic acid, steric acid, oleic acid, linoleic acid, soybean oil) on Sphaerotilus natans, 0B17 (Pseudomonas sp.), and recombinant Escherichia coli DH5(/pUC19/CAB were studied. Oleic acid enhances Poly-3-hydroxybutyrate (PHB) production in these three bacterial strains, suggesting that the single double bond of the acid activates the polyhydroxylkanoate accumulation enzymatic reaction. Under the effect of lauric acid and linoleic acid, the growth of S. natans and 0B17 were totally inhibited. However, the enhanced PHB accumulation in recombinant E. coli was observed.
Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalApplied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology
Issue number1-3
Publication statusPublished - 1 Mar 2005


  • Fatty acids
  • Poly-3-hydroxybutyrate
  • Pseudomonas sp.
  • Recombinant Escherichia coli
  • Sphaerotilus natans

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology


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