Effects of curvature and cell-cell interaction on cell adhesion in microvessels

W. W. Yan, Yang Liu, B. M. Fu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)

Abstract

It has been found that both circulating blood cells and tumor cells are more easily adherent to curved microvessels than straight ones. This motivated us to investigate numerically the effect of the curvature of the curved vessel on cell adhesion. In this study, the fluid dynamics was carried out by the lattice Boltzmann method (LBM), and the cell dynamics was governed by the Newton's law of translation and rotation. The adhesive dynamics model involved the effect of receptor-ligand bonds between circulating cells and endothelial cells (ECs). It is found that the curved vessel would increase the simultaneous bond number, and the probability of cell adhesion is increased consequently. The interaction between traveling cells would also affect the cell adhesion significantly. For two-cell case, the simultaneous bond number of the rear cell is increased significantly, and the curvature of microvessel further enhances the probability of cell adhesion.
Original languageEnglish
Pages (from-to)629-640
Number of pages12
JournalBiomechanics and Modeling in Mechanobiology
Volume9
Issue number5
DOIs
Publication statusPublished - 1 Oct 2010

Keywords

  • Cell adhesion
  • Curved microvessel
  • Lattice Boltzmann method

ASJC Scopus subject areas

  • Biotechnology
  • Mechanical Engineering
  • Modelling and Simulation

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