Effects of aqueous extract from Salvia miltiorrhiza Bunge on serum lipid level and liver in ovariectomized rats

Chun Mei Li, Ri Fu Yang, Qu Liang Gu, Bo Wang, Jian Hong Wu, Xiao Dan Fan, Shun Wan Chan, Tai Qiu Qiu, Man Sau Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

In order to evaluate the estrogenic effect of Salvia miltiorrhiza Bunge (SM), 32 six-month-old female SD rats were randomly divided into 4 groups, namely, sham-operated rats + vehicle (marked as Sham), ovariectomized rats + vehicle (marked as OVX), ovariectomized rats + 17 β-estradiol (1 mg·kg-1·d-1, p.o., marked as E2), ovariectomized rats + SM (600 mg·kg-1·d-1, p.o., marked as SM). After the treatment for 12 weeks, the body weight gain, uterus weight index, serum lipid level, serum transaminase activity and oxidant/antioxidant level were detected, and a histological examination of the liver was carried out. The results show that the treatment with aqueous extract for 12 weeks helps to reduce the body weight gain, stimulate the growth of the atrophic uterus, improve the serum lipid level, decrease the ALT and AST levels in serum and suppress the lipid accumulation in the liver of ovariectomized rats. All these above-mentioned protective effects of SM extract probably relate to the inhibition of oxidant (Methane Dicarboxylic Aldehyde) level and the activity improvement of antioxidant enzymes such as super oxygen dehydrogenises, catalase and glutathione peroxidase.
Original languageChinese (Simplified)
Pages (from-to)151-156
Number of pages6
JournalHuanan Ligong Daxue Xuebao/Journal of South China University of Technology (Natural Science)
Volume40
Issue number12
DOIs
Publication statusPublished - 1 Dec 2012

Keywords

  • Aqueous extract
  • Liver
  • Ovariectomized rat
  • Salvia miltiorrhiza Bunge
  • Serum lipid

ASJC Scopus subject areas

  • General Engineering

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