TY - JOUR
T1 - Effects and safety of vagus nerve stimulation on upper limb function in patients with stroke: a systematic review and meta-analysis
AU - Abdullahi, Auwal
AU - Wong, Wai Lung
AU - Ng, Sheung Mei Shamay
N1 - Funding Information:
We would like to thank the Research Centre for Chinese Medicine Innovation of The Hong Kong Polytechnic University (Grant no. P0041139) and PolyU Distinguished Postdoctoral Fellowship Scheme (Grant no. P0035217) for their support to carry out this research.
Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023/12
Y1 - 2023/12
N2 - Vagus nerve stimulation (VNS) is used to deliver electric current to stimulate the vagus nerve. The aim of this study is to carry out a systematic review and meta-analysis to determine its effects on motor function in patients with stroke. PubMED, Embase, Web of Science (WoS), and Scopus were searched. Data on time since stroke, and mean scores and standard deviation on outcomes such as level of impairment and motor function were extracted. The results showed that invasive (MD 2.66, 95% CI 1.19–4.13, P = 0.0004) and non-invasive (MD 24.16, 95% CI 23.56–24.75, P = 0.00001) VNS are superior at improving level of motor impairment than the control post intervention and at follow-up respectively. Similarly, VNS improved motor function post intervention (MD 0.28, 95% CI 0.15–0.41, P < 0.0001); and there was no significant difference in adverse events between invasive VNS and control (OR 2.15, 95% CI 0.97–4.74, P = 0.06), and between non-invasive VNS and control (OR 4.54, 95% CI 0.48–42.97, P = 0.19). VNS can be used to improve motor function in patients with stroke.
AB - Vagus nerve stimulation (VNS) is used to deliver electric current to stimulate the vagus nerve. The aim of this study is to carry out a systematic review and meta-analysis to determine its effects on motor function in patients with stroke. PubMED, Embase, Web of Science (WoS), and Scopus were searched. Data on time since stroke, and mean scores and standard deviation on outcomes such as level of impairment and motor function were extracted. The results showed that invasive (MD 2.66, 95% CI 1.19–4.13, P = 0.0004) and non-invasive (MD 24.16, 95% CI 23.56–24.75, P = 0.00001) VNS are superior at improving level of motor impairment than the control post intervention and at follow-up respectively. Similarly, VNS improved motor function post intervention (MD 0.28, 95% CI 0.15–0.41, P < 0.0001); and there was no significant difference in adverse events between invasive VNS and control (OR 2.15, 95% CI 0.97–4.74, P = 0.06), and between non-invasive VNS and control (OR 4.54, 95% CI 0.48–42.97, P = 0.19). VNS can be used to improve motor function in patients with stroke.
UR - https://www.scopus.com/pages/publications/85171566074
U2 - 10.1038/s41598-023-42077-2
DO - 10.1038/s41598-023-42077-2
M3 - Journal article
SN - 2045-2322
VL - 13
SP - 1
EP - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 15415
ER -