Abstract
Chiral ferrocene-derived phosphine-thioether mixed donor ligands supported by heterocycles effected the palladium-catalyzed enantioselective allylic alkylations with excellent yields and enantioselectivities (up to 96% ee). With cyclic and unsymmetrical allylic acetates as substrate, the corresponding alkylated products with enantioselectivities up to 87% ee were obtained. Based on X-ray crystallography and NMR studies, the origin of the observed enantioselectivities is discussed. KGaA.
| Original language | English |
|---|---|
| Pages (from-to) | 1412-1422 |
| Number of pages | 11 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 351 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Jun 2009 |
Keywords
- Allylic alkylation
- Asymmetric catalysis
- Enantioselectivity
- Ferrocenes
- Phosphine-thioether ligands
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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