Effect of vasomotion on blood flow distribution in microvessels

J. C. Shao, Yang Liu, Z. D. Su

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)

Abstract

The control of flow in the microcirculation is crucial to ensure blood supply to the tissues. The spontaneous time-dependent contraction and relaxation of small arteries and arterioles was observed 160 years ago and is termed as vasomotion. Vasomotion is an intrinsic phenomenon unrelated to cardiac rhythm or neural and hormonal regulation; and it works as a local control mechanism to regulate the microvascular blood flow. In spite of tremendous studies on vasomotion, the physiological role of vasomotion is not clear. Vasomotion results in the flow oscillation which is termed as flowmotion. The flowmotion is crucial for optimal blood flow and nutrient delivery in micro vasculature. Blood vessels in tumors are highly irregular and dense compared to those in normal tissue which may affect the flowmotion. As the first attempt, in this study we investigated the effect of irregular microvascular structure on flow delivery in microvascular bed with composite flow oscillating frequencies. The results showed that the irregular micro vasculature would decrease the flowmotion and lead to reduction of nutrient and drug delivery which is consistent with the experimental observation.
Original languageEnglish
Title of host publicationFluid-Structure-Sound Interactions and Control - Proceedings of the 3rd Symposium on Fluid-Structure-Sound Interactions and Control
PublisherSpringer Heidelberg
Pages295-299
Number of pages5
ISBN (Print)9783662488669
DOIs
Publication statusPublished - 1 Jan 2016
Event3rd Symposium on Fluid-Structure-Sound Interactions and Control,FSSIC 2015 - Perth, Australia
Duration: 5 Jul 20179 Jul 2017

Publication series

NameLecture Notes in Mechanical Engineering
VolumePart F3
ISSN (Print)2195-4356
ISSN (Electronic)2195-4364

Conference

Conference3rd Symposium on Fluid-Structure-Sound Interactions and Control,FSSIC 2015
CountryAustralia
CityPerth
Period5/07/179/07/17

ASJC Scopus subject areas

  • Automotive Engineering
  • Aerospace Engineering
  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

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