Effect of Erythrina variegata on Ca2+ homeostasis in ovariectomized rats and action mechanism

Yan Zhang, Xiao Li Li, Man Sau Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Objective: To study the effect of Erythrina variegata (EV) on Ca 2+ homeostasis in ovariectomized rats and the regulation on gene expression in duodenum and kidney. Method: Four weeks after surgical operation, the ovariectomized (OVX) rats were administered orally with estradiol and EV extracts for 14 weeks. Ca level in serum and urine was measured by colorimetric methods, and gene expressions in duodenum and kidney were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). Result: EV extracts could improve the serum Ca level and inhibite the urinary Ca excretion in OVX rats, and this might be due to the up-regulation of EV on VDR mRNA expression in duodenum and CaBP-9k mRNA expression in kidney. Conclusion: EV could maintain Ca homeostasis in OVX rats.
Original languageEnglish
Pages (from-to)627-630
Number of pages4
JournalZhongguo Zhongyao Zazhi
Volume32
Issue number7
Publication statusPublished - 1 Apr 2007

Keywords

  • Calcium
  • Erythrina variegata
  • Gene expression
  • Ovariectomy

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Complementary and alternative medicine
  • Pharmacology (medical)

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