Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)

Jia-chi Chiou, Shengbiao Wan, Kin Fai Chan, Pui Kin So, Dandan He, Edward Wai Chi Chan, Tak Hang Chan, Kwok Yin Wong, Jiang Tao, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

80 Citations (Scopus)

Abstract

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys221residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.
Original languageEnglish
Pages (from-to)9543-9546
Number of pages4
JournalChemical Communications
Volume51
Issue number46
DOIs
Publication statusPublished - 11 Jun 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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