Easily accessible and highly tunable Lndolyl phosphine ligands for suzuki-miyaura coupling of aryl chlorides

Chau Ming So, Chak Po Lau, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

119 Citations (Scopus)


This study describes a new class of easily accessible indolyl phosphine ligands, prepared via an efficient protocol involving Fischer indolization from readily available Phenylhydrazine and substituted acetophenones. This versatile ligand scaffold provides beneficial features, including high potential of steric and electronic tunability. The air-stable indolyl phosphines in combination with a palladium metal precursor provide highly effective catalysts for Suzuki-Miyaura coupling of unactivated aryl chlorides, and the catalyst loading down to 0.02 mol % can be achieved.
Original languageEnglish
Pages (from-to)2795-2798
Number of pages4
JournalOrganic Letters
Issue number15
Publication statusPublished - 19 Jul 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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