TY - JOUR
T1 - Early-life exposure to the Chinese famine and risk of carotid intima-media thickness increased in adulthood
AU - Liu, Lin
AU - Huang, Yu qing
AU - Lo, Kenneth
AU - Chen, Chao lei
AU - Li, Jie
AU - Feng, Ying qing
N1 - Funding Information:
This work was supported by the Natural Science Foundation of Guangdong Province (No. 2020A1515010738 ), Science and Technology Plan Program of Guangdong Province (No. 2017B030314041 ), Science and Technology Plan Program of Guangzhou (No. 201604020143 , No. 201604020018 , No. 201604020186 , and No. 201803040012 ), and the National Key Research and Development Program of China (No. 2017YFC1307603 , No. 2016YFC1301305 ), the Key Area R&D Program of Guangdong Province (No. 2019B020227005 ).
Funding Information:
This work was supported by the Natural Science Foundation of Guangdong Province (No.2020A1515010738), Science and Technology Plan Program of Guangdong Province (No.2017B030314041), Science and Technology Plan Program of Guangzhou (No.201604020143, No.201604020018, No.201604020186, and No.201803040012), and the National Key Research and Development Program of China (No.2017YFC1307603, No.2016YFC1301305), the Key Area R&D Program of Guangdong Province (No.2019B020227005).
Publisher Copyright:
© 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
PY - 2021/3/10
Y1 - 2021/3/10
N2 - Background and aims: Little was known about the effect of famine exposure on carotid intima-media thickness (cIMT). The present study aimed to explore the relationship in a Chinese population. Methods and results: Participants were divided into five groups: not exposed to famine, exposed to famine in fetal, early, mid or late childhood. Elevated cIMT was defined as a thickness of >0.9 mm measured by carotid ultrasound. Multivariate logistic regression was performed to calculate odds ratio (OR) and confidence interval (CI) between famine exposure and cIMT. A total of 2637 (970 male, mean age 59.1 ± 3.65 years) participants were recruited, and 491 (18.62%) of them had elevated cIMT. When compared with the non-exposure group, the fully adjusted ORs for increased cIMT for exposure in fetal, early, mid to late childhood were 1.321 (95%CI: 0.872, 1.994, P = 0.186), 1.713 (95% CI: 1.188, 2.483, P = 0.004), 2.359 (95% CI: 1.674, 3.357, P < 0.001) and 2.485 (95% CI: 1.773, 3.518, P < 0.001), respectively. Subgroup analyses showed that the exposure to famine did not interact with body mass index, gender, smoking status, hypertension and diabetes history on its effect on cIMT. Conclusion: Our findings indicated that early-life exposure to the Chinese famine might be associated with an increased risk of increased cIMT in adulthood.
AB - Background and aims: Little was known about the effect of famine exposure on carotid intima-media thickness (cIMT). The present study aimed to explore the relationship in a Chinese population. Methods and results: Participants were divided into five groups: not exposed to famine, exposed to famine in fetal, early, mid or late childhood. Elevated cIMT was defined as a thickness of >0.9 mm measured by carotid ultrasound. Multivariate logistic regression was performed to calculate odds ratio (OR) and confidence interval (CI) between famine exposure and cIMT. A total of 2637 (970 male, mean age 59.1 ± 3.65 years) participants were recruited, and 491 (18.62%) of them had elevated cIMT. When compared with the non-exposure group, the fully adjusted ORs for increased cIMT for exposure in fetal, early, mid to late childhood were 1.321 (95%CI: 0.872, 1.994, P = 0.186), 1.713 (95% CI: 1.188, 2.483, P = 0.004), 2.359 (95% CI: 1.674, 3.357, P < 0.001) and 2.485 (95% CI: 1.773, 3.518, P < 0.001), respectively. Subgroup analyses showed that the exposure to famine did not interact with body mass index, gender, smoking status, hypertension and diabetes history on its effect on cIMT. Conclusion: Our findings indicated that early-life exposure to the Chinese famine might be associated with an increased risk of increased cIMT in adulthood.
KW - Adulthood
KW - Atherosclerosis
KW - Carotid intima-media thickness
KW - Chinese famine
KW - Early life
KW - Exposure
UR - http://www.scopus.com/inward/record.url?scp=85100406675&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2020.08.032
DO - 10.1016/j.numecd.2020.08.032
M3 - Journal article
C2 - 33549438
AN - SCOPUS:85100406675
SN - 0939-4753
VL - 31
SP - 841
EP - 848
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 3
ER -
