Early estimated glomerular filtration rate and depression in kidney transplantation recipients: a longitudinal study

Xiaoqi Wu, Min Liu, Lina Cui, Jia Liu, Lifang Liu, Xiaoxia Wu, Zhimin Wang, Andy Sk Cheng, Jianfei Xie (Corresponding Author), Xiaolian Li (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Depression is a common psychological problem in kidney transplantation (KT) recipients and affects long-term graft outcomes. Estimated glomerular filtration rate (eGFR) as a commonly used indicator of renal function plays a vital role in follow-up detection after KT. The aim of this study is to observe the change of early eGFR within 3 months after KT and to explore the correlation between eGFR and depression before and after transplantation. The Self-rating Depression Scale was used to evaluate depression. Among 135 patients with KT, 128 patients completed the longitudinal study. We used a one-way repeated-measures analysis of variance to analyze eGFR and a generalized estimating equation model to examine the relationship between depression and eGFR in KT recipients with pre-transplant and 30, 60, 90 days post-transplant. The mean eGFR of KT recipients at four time-points was 5.97 ± 4.83, 72.84 ± 26.06, 79.06 ± 26.45 and 81.79 ± 25.62, respectively. The results demonstrated that eGFR kept steady at 60 days and 90 days post-transplant; depression was significantly associated with eGFR. Earlier identification and treatment of depression in KT recipients may be essential to promote their recovery of early renal function.

Original languageEnglish
JournalPsychology, Health and Medicine
Publication statusE-pub ahead of print - 11 Dec 2020


  • depression
  • Glomerular filtration rate
  • kidney transplantation
  • renal function recovery

ASJC Scopus subject areas

  • Clinical Psychology
  • Applied Psychology
  • Psychiatry and Mental health

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