Dynamic Pressure Measurements During Vitrectomy in a Model of the Eye

Irene Nepita, Alessandro Stocchino (Corresponding Author), Andrea Dodero, Maila Castellano, Mariantonia Ferrara, Mario R Romano, Rodolfo Repetto

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)


Purpose: To accurately evaluate pressure changes during vitrectomy in a rigid model of the vitreous chamber and to test the efficiency of the EVA phacovitrectomy system (Dutch Ophthalmic Research Center) in terms of compensation of intraocular pressure variations. Methods: We tested 23-, 25-, and 27-gauge double-blade vitreous cutters in both vented global pressure control and automatic infusion compensation (AIC) modes in a vitreous chamber model, mimicking the real surgical procedure. Balanced salt solution and artificial vitreous, similar to the real vitreous body, were used. We tested both standard-flow (SF) and high-flow (HF) infusion systems, varying the infusion pressure between 20 and 40 mm Hg. In each experiment, flow rate was also measured. Results: Pressure drop was rapidly and efficiently compensated when 23-and 25-gauge cutters were used in AIC mode, with infusion pressures ranging between 30 and 55 mm Hg. The 27-gauge cutter was less efficient in compensating pressure variations. Pressure fluctuations related to the high-frequency motion of the cutter blade were small compared to the overall pressure variations. The use of the HF infusion system resulted in larger flow rates and lower pressure changes compared to the SF infusion system. Conclusions: Despite the rigid material of the model, the present pressure measurements are in line with previous studies performed on porcine eye. The use of AIC mode compensates intraoperative pressure drops efficiently, with both 23-and 25-gauge cutters. The HF infusion system is more efficient than the SF infusion system. Translational Relevance: The AIC infusion mode efficiently compensates intraopera-tive pressure drops, in both 23-and 25-gauge experimental vitrectomy. The HF infusion system resulted in larger flow rate and lower pressure changes.

Original languageEnglish
Article number21
Pages (from-to)21-21
Number of pages1
JournalTranslational Vision Science Technology
Issue number5
Publication statusPublished - May 2022


  • IOP measurements
  • pressure compensation, artificial vitreous
  • vitrectomy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology


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