Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5:Yb/Er

Songjun Zeng, Ming Kiu Tsang, Chi Fai Chan, Ka Leung Wong, Bin Fei, Jianhua Hao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

89 Citations (Scopus)


A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.
Original languageEnglish
Pages (from-to)5118-5124
Number of pages7
Issue number16
Publication statusPublished - 21 Aug 2012

ASJC Scopus subject areas

  • Materials Science(all)

Cite this