TY - JOUR
T1 - Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds
AU - Qiu, Haoyu
AU - Lan, Guangqian
AU - Ding, Weiwei
AU - Wang, Xinyu
AU - Wang, Wenyi
AU - Shou, Dahua
AU - Lu, Fei
AU - Hu, Enling
AU - Yu, Kun
AU - Shang, Songmin
AU - Xie, Ruiqi
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 52103096), Natural Science Foundation of Chongqing, China (grant number cstc2020jcyj-msxmX0383), Fundamental Research Funds for the Central Universities (grant number SWU-KT22004), Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars (cx2019050), and Innovation Project for Graduate Student of Chongqing (CYB21121).
Publisher Copyright:
Copyright © 2022 Haoyu Qiu et al.
PY - 2022/5/21
Y1 - 2022/5/21
N2 - Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites. In this study, a Janus particle, SEC-Fe@CaT with dual-driven forces, bubble-driving, and magnetic field– (MF–) mediated driving, was prepared via in situ loading of Fe3O4 on a sunflower sporopollenin exine capsule (SEC), and followed by growth of flower-shaped CaCO3 clusters. The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration, and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds. During the movement in blood flow, the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells (RBCs) to release procoagulants, thus promoting activation of platelet and rapid hemostasis. Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models, respectively. In contrast, the similar commercial product Celox™ required approximately 70 s to stop the bleeding in both bleeding modes. This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds. It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.
AB - Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites. In this study, a Janus particle, SEC-Fe@CaT with dual-driven forces, bubble-driving, and magnetic field– (MF–) mediated driving, was prepared via in situ loading of Fe3O4 on a sunflower sporopollenin exine capsule (SEC), and followed by growth of flower-shaped CaCO3 clusters. The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration, and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds. During the movement in blood flow, the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells (RBCs) to release procoagulants, thus promoting activation of platelet and rapid hemostasis. Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models, respectively. In contrast, the similar commercial product Celox™ required approximately 70 s to stop the bleeding in both bleeding modes. This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds. It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.
UR - http://www.scopus.com/inward/record.url?scp=85132339174&partnerID=8YFLogxK
U2 - 10.34133/2022/9762746
DO - 10.34133/2022/9762746
M3 - Journal article
AN - SCOPUS:85132339174
SN - 2096-5168
VL - 2022
JO - Research
JF - Research
M1 - 9762746
ER -