Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia

Yuen Shan Ho, Kwok Fai So, Raymond C. Chang

Research output: Journal article publicationReview articleAcademic researchpeer-review

45 Citations (Scopus)

Abstract

Alzheimer's disease and vascular dementia are two major diseases associated with dementia, which is common among the elderly. While the etiology of dementia is multi-factorial and complex, neurodegeneration may be the major cause of these two diseases. Effective drugs for treating dementia are still to be discovered. Current western pharmacological approaches against neurodegeneration in dementia develop symptom-relieving and disease-modifying drugs. Current integrative and holistic approaches of Chinese medicine to discovering drugs for neurodegeneration in dementia include (1) single molecules from the herbs, (2) standardized extracts from a single herb, and (3) herbal formula with definite composition. This article not only reviews the concept of dementia in western medicine and Chinese medicine but also evaluates the advantages and disadvantages of these approaches.
Original languageEnglish
Article number15
JournalChinese Medicine
Volume6
DOIs
Publication statusPublished - 22 Apr 2011
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine

Cite this