Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

L. K. Chin; K. Q. Luo; W. Park; M. Je; J. Tsai; D. L. Kwong; A. Q. Liu

doi:10.1109/MEMSYS.2012.6170309

Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

L. K. Chin, K. Q. Luo, W. Park, M. Je, J. Tsai, D. L. Kwong, A. Q. Liu

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

1 Citation (Scopus)

Abstract

This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.

Original language	English
Title of host publication	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages	808-811
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2012.6170309
Publication status	Published - Feb 2012
Externally published	Yes
Event	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France Duration: 29 Jan 2012 → 2 Feb 2012

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/Territory	France
City	Paris
Period	29/01/12 → 2/02/12

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

More information

10.1109/MEMSYS.2012.6170309

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Chin, L. K., Luo, K. Q., Park, W., Je, M., Tsai, J., Kwong, D. L., & Liu, A. Q. (2012). Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 (pp. 808-811). Article 6170309 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2012.6170309

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title = "Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis",

abstract = "This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.",

author = "Chin, {L. K.} and Luo, {K. Q.} and W. Park and M. Je and J. Tsai and Kwong, {D. L.} and Liu, {A. Q.}",

year = "2012",

month = feb,

doi = "10.1109/MEMSYS.2012.6170309",

language = "English",

isbn = "9781467303248",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

pages = "808--811",

booktitle = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012",

note = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 ; Conference date: 29-01-2012 Through 02-02-2012",

}

Chin, LK, Luo, KQ, Park, W, Je, M, Tsai, J, Kwong, DL & Liu, AQ 2012, Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. in 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012., 6170309, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 808-811, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 29/01/12. https://doi.org/10.1109/MEMSYS.2012.6170309

Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. / Chin, L. K.; Luo, K. Q.; Park, W. et al.
2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 808-811 6170309 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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AU - Kwong, D. L.

AU - Liu, A. Q.

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AB - This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.

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Chin LK, Luo KQ, Park W, Je M, Tsai J, Kwong DL et al. Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 808-811. 6170309. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2012.6170309

Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

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